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Revolutionizing Cancer Treatment Planning Tools, this Company’s Innovative Technologies are Changing the Game in the Fight Against Cancer…

Introducing: AccuStem Sciences, Inc. (OTCQB: ACUT), a clinical stage diagnostics company dedicated to improving outcomes for patients with cancer.

The Company’s mission is to provide innovative treatment planning tools that optimize outcomes and quality of life for patients along the continuum of oncology care, from cancer screening through treatment and monitoring.

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    With a $1.3BN market opportunity in breast cancer alone, AccuStem is an exciting first mover opportunity as it addresses needs no other company or product does!

    The Company’s mission is to provide innovative treatment planning tools that optimize outcomes and quality of life for patients along the continuum of oncology care, from cancer screening through treatment and monitoring.

    AccuStem is the only known company evaluating tumor “stemness” which can help determine the best course of treatment for patients and change clinical approach.

    “Stemness” indicates how much a tumor behaves like stem cells. Knowing a patient’s “stemness” levels can help determine the level of treatment aggressiveness each individual patient needs. This means, patients with a lower stemness level may avoid unnecessary treatments while patients with higher “stemness” levels can attack the cancer more aggressively with better outcome. 

    Breast cancer is one of the most common types of cancer today. According to the American Cancer Society, approximately 297,790 new cases of invasive breast cancer will be diagnosed in women in 2023 in the United States alone. 

    The Company has an estimated market opportunity of a massive $1.3BN in breast cancer alone!

    AccuStem Sciences, Inc. (OTCQB: ACUT) is a trailblazer in the oncology treatment planning tools market and its technology has the potential to be a total game-changer for cancer patients!

    ACUT recently extended its partnership with Instituto Europeo di Oncologia (IEO), one of the most renowned comprehensive cancer centers in Europe. This exciting milestone will help support the company’s mission. 

    The Company’s technology, StemPrintER has been shown to outperform the current market leader in risk of recurrence testing for women with early-stage breast cancer.

    This study conducted by investigators from the IEO in Milan and The Royal Marsden Hospital in London evaluated patients from the TransATAC trial, which is a well-known clinical trial that compared different treatments for early-stage breast cancer. The study included an evaluation of several breast cancer risk scoring assays, including the market-leading OncotypeDX test from Exact Sciences Corporation (NASDAQ: EXAS), which makes $600M annually!

    The study found that AccuStem's StemPrintER test was effective at predicting the likelihood of distant recurrence of breast cancer, with high-risk patients up to 4 times more likely to experience recurrence than low-risk patients. Additionally, StemPrintER was found to outperform the OncotypeDX test in stratifying patients based on their risk of breast cancer recurrence!

    AccuStem Sciences, Inc. (OTCQB: ACUT) outperforming the market leader makes the Company a first mover opportunity!

    HIGHLIGHTS:

    1. Innovative Technology: AccuStem's StemPrintER was found to outperform the market-leading OncotypeDX which makes $600M annually.
    2. Massive Market Potential: According to a recent market research report, the global market for breast cancer diagnostics, including genomic tests like OncotypeDX, is projected to grow to over $8 billion by 2027. With an estimated market opportunity of a massive $1.3BN in breast cancer alone, the Company is well positioned to capture this market opportunity.
    3. Profit Margins: The Company’s profit margins are projected to be similar to large pharma companies reaching 90% at scale.
    4. Strong Acquisition Target: “Stemness” is applicable to all solid tumor types which makes ACUT a strong acquisition target as no one else is doing this!
    5. Strong Intellectual Property Portfolio: ACUT has a strong intellectual property portfolio, including multiple issued and pending patents, which can provide a competitive advantage and help protect its market position.
    6. Successful Clinical Trials: AccuStem's technology has undergone successful clinical trials with patients and the analyses included more than 3,000 patients. The trials have demonstrated promising results in predicting the likelihood of breast cancer recurrence and informing surgical approach.
    7. Addressing Unmet Needs: ACUT’s technology is designed to address unmet needs in cancer diagnosis defining optimal surgical intervention for patients with early breast cancer diagnosis. As such, the company's technology has the potential to fill a significant gap in the current standard of care, which can drive adoption and revenue growth.
    8. Experienced Management Team: The company's management team includes experienced leaders with a track record of success in the biotechnology industry, which can help guide the company's growth and navigate potential challenges.
    9. Strong Partnerships: AccuStem has established partnerships with several leading academic institutions and biotechnology companies, which can provide access to additional resources, expertise, and potential collaboration opportunities.
    10. Diversified Product Pipeline: In addition to its flagship StemPrintER technology, AccuStem has a diversified product pipeline plan that includes treatment planning tools for other types of cancer.

    With an estimated market opportunity of a massive $1.3BN in breast cancer alone, AccuStem Sciences, Inc. (OTCQB: ACUT) is an innovative game-player in the oncology market to have on your watch-list!

    The breast cancer market is a large and growing segment of the healthcare industry that has significant unmet needs. According to a recent market research report, the global market for breast cancer diagnostics, including genomic tests like OncotypeDX, is projected to grow to over $8 billion by 2027. 

    This growth can be attributed to several different factors, including increasing diagnoses of breast cancer worldwide, advancements in diagnostic technologies, and a growing focus on personalized medicine and targeted therapies.

    AccuStem Sciences, Inc. (OTCQB: ACUT)’s disruptive technology is an important player in the risk assessment of cancer patients as it answers important clinical questions and can point to surgical intervention to improve patient outcomes.

    About the Company:

    Founded in 2020 as a spinoff from Tiziana Life Sciences to commercialize a wide array of oncology products, AccuStem is a clinical stage diagnostics company dedicated to optimizing outcomes and quality of life for patients with cancer. The Company plans to drive innovation in healthcare by offering proprietary molecular testing that addresses unmet clinical needs from cancer screening through treatment and monitoring. By interrogating novel disease pathways, such as tumor “stemness”, the company believes its tools will help care teams better understand the biology of each patient’s cancer, leading to more informed decision making and better possibilities of successful outcomes.

    Stemness in Cancer

    “Stemness” indicates how much a tumor behaves like stem cells. This characteristic is often associated with tumor aggressiveness, resistance to treatment, and higher rates of recurrence.  Levels of stemness are a key feature for understanding cancer progression and in many cases the source of its survival.

    Understanding the level of “stemness” in a patient's tumor can provide valuable insights into its biology, which in turn can help guide treatment decisions and improve patient outcomes.

    This is why the world needs technology like AccuStem's StemPrintER technology. By testing for stemness in breast cancer cells, StemPrintER has the potential to provide more accurate and personalized risk assessments for patients, as well as identify those who are at higher risk for recurrence and could benefit from more aggressive treatment strategies. 

    • High “stemness” in tumors is considered a primary rationale for disease recurrence and/or lack of response to chemotherapy and radiation 
    • Surgery may be the only way to effectively kill cancer stem cells or high “stemness” tumors

    ACUT’s Breast Cancer Program:

    • In-licensed StemPrintER assay from Instituto Europeo di Oncologia (IEO) US and EU patents approved 
    • Planning to address unanswered surgical clinical questions with its assay maximizing first mover advantage
    • The Company’s assay has been validated in multiple clinical trials enrolling 3,000 patients
    • Planning on submitting compelling new data to the 2023 San Antonio Breast Cancer Symposium (SABCS) for a new indication in breast cancer
    •  Will expand into offering high value ancillary testing
    • In a pivotal study, StemPrintER outperformed the market leading OncotypeDX test, which makes $600M annually!

    ACUT’s Stemness Program:

    • “Stemness” technology is applicable to multiple solid tumor types giving the Company numerous 1st mover opportunities pursuing signal seeking in lung and prostate cancers 
    • Clinical questions identified via work with leading lung and prostate physicians
    • StemPrintER evaluated in a Cancer Genome Atlas lung cancer cohort

    Opportunity for ACUT in Lung Cancer:

    2M+ new lung cancer diagnoses annually 

    • Currently no other genomic tests inform risk of recurrence and whether a patient should have surgery or radiation when considering a definitive treatment plan

    StemPrintER may inform surgical approach in patients with early stage lung cancer

    Opportunity for ACUT in Prostate Cancer:

    1.4M+ new prostate cancer diagnoses annually 

    • Currently no other genomic tests inform risk of recurrence and whether a patient should have surgery or radiation when considering a definitive treatment plan.

    StemPrintER may inform surgical approach  in patients with localized prostate cancer

    Leadership:

    With a leadership team that has approximately 60 combined years of experience in the oncology diagnostics sector, this team has a proven track record of successful launch/relaunch strategies.

    Wendy Blosser
    Chief Executive Officer 

    Wendy brings 25 years of success launching, relaunching and building organizations in diagnostic, surgical and capital sales, with a focus in Oncology and Women’s Health. She has achieved record revenue growth at a variety of organizations from early-stage start ups to Fortune 500 companies. Most recently, Wendy has served as CCO at Agendia, Animated Dynamics and Biodesix. Prior to Biodesix, Wendy served as VP of Sales with Integrated Oncology (LabCorp subsidiary) where she led the 

    successful integration of Genzyme Genetics following its acquisition for $925M. Before joining Integrated Oncology, she held several leadership roles with Cytyc Corporation prior to its $6.2B acquisition by Hologic.

    Jeff Fensterer
    Chief Operating Officer

    Jeff has spent the last 20 years with start ups at various organizational stages, leading marketing and product strategy in his most recent roles at Agendia, Animated Dynamics and Biodesix. His scientific expertise and keen commercial perspective enable organizations to take clinical data and translate it into impactful product messaging and publication strategies. His exceptional track record in long-term strategic planning is enhanced by experience in a broad spectrum of roles including marketing, sales, R&D, market access, lab operations, clinical development, business development and IT. Jeff holds a MBA from Carnegie Mellon University.

    Joe Flanagan
    Chief Business Officer

    Joe has 25 years of sales excellence experience and is one of the most sought after talents in Oncology. He is a strategic expert, playing a leading role in the commercial development and successful launch of several product offerings from early-stage diagnostic start ups to large pharmaceutical companies. Prior to joining Accustem, Joe served as the VP of Sales for Precision Therapeutics as well as the VP of Market Development for Biodesix and Agendia. During his tenure, record revenues were realized as a result of his efforts to enhance the clinical agility and logistical focus of each company’s sales team. Most recently, he led strategic development efforts with Ambry Genetics’ Oncology franchise.

    Keeren Shah
    Chief Finance Officer

    Keeren has held a variety of leadership roles in Finance over the last 20 years. In addition to serving as AccuStem’s Chief Financial Officer, she also serves as the Chief Financial Officer of OKYO Pharma Ltd, Tiziana Life Sciences, Ltd. and Rasna Therapeutics Inc., having previously served as the Group Financial Controller for all businesses from June 2016 to July 2020. Prior to joining this portfolio of companies, Keeren spent 10 years at Visa, Inc. as a senior leader on its Finance team where she was responsible for key financial controller activities, financial planning and analysis, core processes as well as leading and participating in key transformation programs including Visa Inc.’s initial public offering. Before joining Visa, Keeren also held a variety of finance positions at other leading companies including Arthur Andersen and BBC Worldwide. She holds a Bachelor of arts with honours in Economics and is a member of the Chartered Institute of Management Accountants.

    In Summary…

    ACUT’s mission is to provide treatment planning tools to address important, clinical needs that have previously not been answered across a spectrum of tumor types, making this Company an exciting first mover opportunity!

    AccuStem’s disruptive technology could be integral for patients with cancer, as it could improve outcomes and reduce healthcare costs while determining the optimal surgical approach for patients. 

    With an estimated market opportunity of a massive $1.3BN in breast cancer alone and a 90% margin opportunity, ACUT is a trailblazer with massive market opportunity to keep your eye on.

    The Company’s technology, StemPrintER has been shown to outperform the current market leader in risk of recurrence testing for women with early-stage breast cancer making this an exciting Company to keep your eye on in a massive market!

    With strong patent protection, pharma-like margins, successful clinical trials that outperform the market leader, and building a body of evidence that makes ACUT a strong acquisition target, AccuStem Sciences, Inc. (OTCQB: ACUT), is a massive revenue opportunity and should be on your watch-list!

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