The biotech space ended on a very BULLIsh note last week and this underfollowed biotech company may be the next to see blue-sky growth

Greetings All,

As 2023 inches closer to an end, there are still a few weeks to go to uncover phenomenal and promising companies to keep your eyes on this year and beyond.

The biotech arena had an exciting finish in the last week after Big Pharma’s $10.1 billion deal splash.

Stocks in the space saw a lift on the news that AbbVie announced plans to buy cancer developer ImmunoGen for $31.26 a share. This marks about a 95% premium to Immunogen’s closing price last Wednesday!

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    With momentum going, now is the time to have underfollowed biotech company Phio Pharmaceuticals Corp. on your radar.

    The NASDAQ-traded stock trades under the ticker symbol “PHIO.”

    PHIO is a clinical-stage biotech co-founded by the Nobel scientist who discovered RNA interference.

    The stock is currently trading a little over $1 and carries a “STRONG BUY” rating at

    In an August report,  Vernon Bernardino from H.C. Wainwright reiterated a “BUY” rating on Phio Pharmaceuticals (PHIO – Research Report), with a price target of $6.00. According to TipRanks, Bernardino is a 4-star analyst with an average return of 10.0%

    A $6 price target indicates a potential upside of 400%! And this is just one reason to have PHIO on your radar!

    Who is Phio Pharmaceuticals Corp.?

    PHIO is a clinical-stage biotechnology company whose proprietary INTASYL™ RNAi platform technology is designed to make immune cells more effective in killing tumor cells.

    What is Intasyl?

    INTASYL is the only self-delivering RNAi technology focused on immuno-oncology therapeutics. 

    INTASYL drugs are designed to precisely target specific proteins that reduce the body's ability to fight cancer, without the need for specialized formulations or drug delivery systems.

    INTASYL is a patented precision delivery technology that delivers uniquely designed gene-silencing compounds to any gene target in the human genome.

    It effectively targets messenger RNA to suppress specific proteins, genetically encoded in the DNA, that can interfere with the body’s immune cells in killing cancer cells, resulting in the reduction of specific protein targets. It has been safely tested in human trials in >170 patients.

    The INTASYL technology facilitates the creation of unique, chemically modified siRNA compounds (INTASYL compounds), which can be delivered to a broad range of cell types and tissues without the need for enhancements. INTASYL’s innovative approach features a simplified chemical composition, effectively reducing toxicity and enhancing tolerability and efficacy. This technology is adaptable to both intra-tumoral and adoptive cell therapy (ACT) applications, ensuring a versatile and potent therapeutic platform for gene silencing.

    See how it works in this video HERE:

    Key Clinical Initiatives & Programs:


    The Phase 1b trial is a non-comparative study of neoadjuvant monotherapy using PH-762 in adult patients with cutaneous squamous cell carcinoma, melanoma, or Merkel cell carcinoma. The trial is designed to evaluate the safety and tolerability of neoadjuvant use of intratumorally injected PH-762, assess the tumor response, and determine the dose or dose range for continued study of PH-762.

    Learn more about the clinical trial.


    PH-894 is designed to silence the BRD4 protein. Overexpression of BRD4 is often associated with cancer progression, invasion, and metastasis. What sets PH-894’s approach to silencing BRD4 apart is its dual activity in suppressing BRD4 in both T cells and in tumor cells: PH-894’s suppression of BRD4 in T cells results in T cell activation; additionally, suppression of BRD4 in tumor cells results in tumors becoming more sensitive to T-cell killing.

    Learn more

    A Big Development on PH-762:

    PH-762, the company’s lead pipeline product, has received an investigational new drug (IND) application clearance from the FDA to initiate a clinical study on skin cancer indications.

    The FDA's clearance of the IND application for PH-762 marks a significant step toward the company's evolution from drug discovery to clinical development.

    And recently… the company enrolled the first patient in the company’s U.S. clinical trial with PH-762!

    “The initiation of enrollment in this trial represents a milestone as we develop PH-762 for the treatment of squamous cell and other skin cancers. We are optimistic that this novel, alternative immuno-oncology therapy may offer patients and their care providers, enhanced therapeutic outcomes while minimizing invasive intervention,” said President & CEO, Robert Bitterman.

    Favorable Data on Cancer Drug Candidate PH-894:

    Data from the first study showed that melanoma cells treated with PH-894 enhance their recognition of immune cells. This, in turn, increases their susceptibility to destruction by T cells. 

    Based on this data, management concluded that PH-894 offers a strategy to reduce BRD4 expression (a protein associated with cancer growth) and simultaneously boost the immune response to cancer cells while minimizing the toxicities commonly associated with traditional systemic therapies.

    Data from another study demonstrated the effectiveness of PH-894 as an antitumor cytotoxic agent, i.e., directly killing tumor cells!

    This is based on in vitro tests conducted by management on multiple cancer cell lines (like breast cancer, lung cancer and ovarian cancer, among others) wherein treatment with PH-894 induces concentration-associated apoptosis (i.e., the process of programmed cell death).

    In Summary…

    t’s hard to match the importance of the cancer realm in the biotech arena. Cancer is a disease that has even the biggest biotech companies scrambling to find treatments for.

    With two exciting candidates in its pipeline and studies underway, PHIO is a biotech company to keep your eyes closely on! Any encouraging data could be a catalyst for building shareholder value.

    Keep in mind that PHIO has a $6 price target! This is one biotech company to not dismiss as 2023 comes to an end. 

    PHIO’s proprietary RNAi technology INTASYL™is designed to make immune cells more effective in killing tumor cells.

    2024 could be a game-changing year for PHIO as it revolutionizes the way scientists think about precision medicine.


    Learn More about Phio Pharmaceuticals by gaining access to the latest research report

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