By halting cancer cells’ ability to invade and metastasize! It has the potential to FORCE cancer stem cells to become BENIGN!
The company’s approach addresses a global, unmet medical need of tumor recurrence and metastasis from solid tumors. The Global Metastatic Cancer Treatment Market is estimated to reach $111B by 2027.
The global oncology landscape continues to evolve. There are ongoing efforts to discover, develop, and provide innovative treatments aimed at improving outcomes for a growing number of cancer patients.
The biotech arena was recently boosted by the announcement of AbbVie buying Immunogen, a maker of targeted cancer drugs, for a staggering $10 billion. Cancer is a big business and big pharma is paying big money to stay ahead.
According to Fortune Business Insights’ findings, the global market for oncology drugs reached a value of $184.95 billion in 2022. Projections indicate significant growth, with the market expected to increase from $205.52 billion in 2023 to an estimated $484.32 billion by 2030, representing a compound annual growth rate of 13% during the forecast period.
Oncology drugs include a wide range of treatments, including targeted therapies, chemotherapy agents, immunotherapies, and hormone therapies, all developed to combat cancer.
A Big problem…
Conventional cancer therapies do not always work.
PPCB’s lead candidate PRP represents a new advancement in the treatment of cancer by inducing cell differentiation, impairing angiogenesis, inhibiting cancer stem cell formation, and blocking the EMT process, known as differentiation therapy. This is an exciting anti-cancer stem cell therapy!
Propanc Biopharma is a clinical-stage biopharmaceutical company developing new cancer treatments for solid tumors. Propanc has developed a formulation of anti-cancer compounds designed to control or prevent tumors from recurring and spreading throughout the body by using proenzymes, which are inactive enzyme precursors.
The company intends to target patients with limited therapeutic options for the treatment of solid tumors, initially pancreatic, ovarian, or colorectal tumors.
PPCB’s novel proenzyme therapy is based on the science that enzymes stimulate biological reactions in the body, especially enzymes secreted by the pancreas. These pancreatic enzymes could represent the body’s primary defense against cancer!
PRP controls cancer cell migration, inhibits tumor blood vessel formation, and triggers the cell’s death.
Metastasis occurs because a program inside the cell called the Epithelial-Mesenchymal Transition (EMT) is activated, which causes epithelial cancer cells to become invasive and stem cell-like, allowing these cancer cells to spread and metastasize.
The company’s lead product, PRP, is a mixture of two proenzymes, trypsinogen and chymotrypsinogen from the bovine pancreas, administered by intravenous injection.
Enzyme therapy allows us to fight cancer, using natural elements already found within our organism. Enzymes are natural proteins that stimulate and accelerate biological reactions in the body. The enzymes that are secreted by the exocrine pancreas are essential for the digestion of proteins and fats.
More than one hundred years ago, Professor John Beard first proposed that pancreatic enzymes represent the body’s primary defense against cancer and would be useful as a cancer treatment. Since then, several scientists have endorsed Beard´s hypothesis with encouraging data from patient treatment.
Studies show the effects of Propanc’s PRP on reducing chemoresistance in pancreatic tumor cells.
PPCB has announced that PRP enhances the sensitivity of resistant pancreatic tumor cells to standard chemotherapy treatment and alters the tumor microenvironment by decreasing the fibrotic tissue and its malignancy.
The results were reported by the Company’s joint researcher, Mrs. Belén Toledo Cutillas, MSc, at the laboratory of Professor Macarena Perán, PhD, University of Jaén, Granada, Spain.
Various methods, including apoptosis (programmed cell death) and viability analysis, live/dead assays, and RT-qPCR (real time quantification of gene expression) analyses confirmed PRP enhances the sensitivity of pancreatic tumor cells to standard chemotherapy treatment and decreases expression of genes related to chemoresistance.
It was also proven that a major pathway, TGF-β, responsible for tumorigenesis (production or formation of tumors) and metastasis (cancer spread), is involved with the observed effects by inhibiting this pathway after PRP treatment.
Similar analyses and an in vivo (in a living organism) study evaluating the effects on the tumor microenvironment confirmed transformational changes to the extracellular matrix components of the resistant tumors and according to Mrs. Cutillas, “seems to re-educate the malignant tumor cells by inducing apoptosis and reversing their malignant phenotype (cellular characteristics).
“Results from the experiments conducted by Belen demonstrates the effects of PRP on reducing chemoresistance in pancreatic tumor cells, which is a significant issue among pancreatic adenocarcinoma (PDAC) patients, who have a poor 5-year survival rate of less than eight percent. We look forward to investigating the clinical effects in patients as we progress with future planned clinical trials, where an opportunity for a combinatorial therapeutic strategy may be uncovered to treat these resistant tumors.” - Dr Julian Kenyon, MD, MB, ChB, Propanc’s Chief Scientific Officer
PPCB will target the Peter Mac Cancer Center in Melbourne, Australia, as the site for the First-In-Human (FIH) study for PRP in patients with advaAnced solid tumors.
Initial discussion held previously with the Clinical Investigator confirmed the remaining development activities to be conducted by the Company prior to filing the clinical trial application for the FIH study. This includes the finished drug product manufacture and validation of the bioanalytical method to analyze the pharmacokinetics (movement of drug within the body) of PRP during the study.
80% of all cancers are solid tumors and PPCB is initially targeting:
When he revealed in an email from a hospital bed in 2004 that he had a rare form of pancreatic cancer, former Apple CEO Steve Jobs' health became a topic of intense interest and it shed a light on pancreatic cancer. Other celebrities who have succumbed to the disease include Alex Trebek, Ruth Bader Ginsburg, and Aretha Franklin.
Thousands of regular people have died from the painful disease and their families and friends have suffered with them.
The American Cancer Society’s estimates for pancreatic cancer in the United States for 2023 are:
Just looking at these numbers shows that out of roughly 64,000 cases diagnosed, about 50,000 people will die. That’s a huge number.
Major players in the pancreatic cancer drugs market include Eli Lilly and Company, Pfizer, Novartis AG, Amgen, Celegene Corporation, and GlaxoSmithKline and Abbvie Inc. These are well-established companies with tremendous market caps.
Colorectal cancer is on the rise in an alarming trend. The diagnoses of colorectal (colon) cancer are on the rise in people under age 50. This led the U.S. Preventative Services Task Force to change its recommendations in May 2021 for colon cancer screenings to begin at age 45!
Changes in the gut microbiome may be influencing the increasing rates of colorectal cancer in adults under 50. Studies have shown that diet, obesity, exercise, and some drugs (such as antibiotics) can all change the number and types of bacteria in our gut.
Every 3 years, the American Cancer Society provides an update of CRC statistics based on incidence from population-based cancer registries and mortality from the National Center for Health Statistics. In 2023, approximately 153,020 individuals will be diagnosed with CRC and 52,550 will die from the disease, including 19,550 cases and 3750 deaths in individuals younger than 50 years.
Ovarian cancer is the sixth most common cancer in the world and one of the most aggressive reproductive cancers among women. Most ovarian cancers are diagnosed at late stages (stage 3 or 4) due to the typical absence of symptoms and lack of screening approaches.
Late-stage diagnosis results in relatively high risks of recurrence and often poor prognosis. While the five-year survival rate for stage 1 ovarian cancer is over 80%, the corresponding survival rate for Stage 4 cancer is 20%. Worldwide, over 200,000 cases of ovarian cancer are diagnosed annually.
PPCB provides a competitive advantage over other treatments available. Current drugs in the market offer, at most, a few months of extra life or tumor stabilization.
The company’s long-term therapy based on a pancreatic proenzyme formulation prevents tumor recurrence and metastasis, the main cause of patient death from cancer.
The growing demand for new cancer treatments can be attributed to a rapidly aging population and changing environmental factors in Western countries. The chances of developing cancer increase as a person gets older because more time has been available for mutations to accumulate.
According to the World Health Organization, all cancers (excluding non-melanoma skin cancer) are expected to increase from 8.2 million deaths, in 2012, to more than 10 million deaths by 2020, exceeding 13 million annual deaths by 2030.
Players in the oncology sector are thriving and Propanc Biopharma, Inc. (OTC: PPCB) may emerge as the next victor in this burgeoning arena. 2024 could be a breakout year for the company!
"Despite facing significant global challenges in recent years as a micro-cap company, we face the future heading into the new financial year with growing optimism. We expect to enter clinical development stage with PRP, which management believes will identify a new therapeutic approach to the treatment and prevention of metastatic cancer, which remains the main cause of patient death for sufferers. PRP does not exhibit the same severe or even serious side effects compared to standard therapies – no hair loss, no nausea, no immune suppression – which is an important consideration for patients and their loved ones. We also expect to capitalize on the significant groundwork over the last 15 years, reflected in recent advancements, such as our growing IP portfolio, which now includes 76 patents filed in major, global jurisdictions.”
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